Fri Oct 14 2022

22 articles - From Friday Oct 07 2022 to Friday Oct 14 2022

parm_toc.knit

Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…

Kidney Int

Diabetes management in chronic kidney disease: a consensus report by the American Diabetes Association (ADA) and Kidney Disease: Improving Global Outcomes (KDIGO).

Consensus statements provide specific guidance on use of renin-angiotensin system inhibitors, metformin, sodium-glucose cotransporter-2 inhibitors, glucagon-like peptide 1 receptor agonists, and a nonsteroidal mineralocorticoid receptor antagonist. These areas of consensus provide clear direction for implementation of care to improve clinical outcomes of people with diabetes and CKD.

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Nephrol Dial Transplant

Chronic kidney disease as cardiovascular risk factor in routine clinical practice: a position statement by the Council of the European Renal Association.

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Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Kidney Dis

Cardiorenal Outcomes Among Patients With Atrial Fibrillation Treated With Oral Anticoagulants.

Among patients with non-valvular AF treated in routine clinical practice, compared with VKA, DOAC use was associated with a lower risk of CKD progression, AKI, and major bleeding, but a similar risk of the composite of stroke/systemic embolism and death.

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Focal Segmental Glomerulosclerosis Complicating Therapy With Inotersen, an Antisense Oligonucleotide Inhibitor: A Case Report.

This case adds to spectrum of renal disease associated with inotersen and indicates that discontinuation of the drug alone may result in resolution of renal complications without additional immunosuppression. Monitoring of renal function is essential in patients with ATTRv receiving inotersen, particularly if there is evidence of existing renal amyloid.

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Improving a Rare Metabolic Disorder Through Kidney Transplantation: A Case Report of a Patient With Lysinuric Protein Intolerance.

However data on kidney transplantation in LPI patients is limited and up till now no data on clinical and biochemical improvement after kidney transplantation has been reported. In this case report we describe a rare case of kidney transplantation in a LPI patient with significant improvement in protein tolerance, plasma and urine levels of ornithine, lysine and arginine and on LPI symptoms.

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Clin J Am Soc Nephrol

Genome-Wide Association Study for eGFR in a Taiwanese Population.

We examined these loci with ) were prioritized as critical candidates. Functional analyses delineated novel pathways related to kidney physiology in Taiwanese and East Asian ancestries.

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Kidney Protective Effects of SGLT2 Inhibitors.

Additionally, these drugs stimulate phosphate and magnesium reabsorption and increase uric acid excretion. Familiarity with kidney specific mechanisms of action, potential changes in kidney function, and/or alterations in electrolytes and volume status which are induced by these widely prescribed drugs will facilitate usage in patients for whom they are indicated.

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Nephrol Dial Transplant

Total cortical interstitial inflammation predicts chronic kidney disease progression in patients with lupus nephritis.

In contrast to the current NIH interstitial inflammation classification, accounting for interstitial inflammation in the entire cortical parenchyma allows to identify patients at risk for CKD progression in LN.

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Trimethoprim-sulfamethoxazole and the risk of a hospital encounter with hyperkalemia: a matched population-based cohort study.

The 14-day risk of a hospital encounter with hyperkalemia was higher in patients newly treated with TMP-SMX vs amoxicillin, and the risk was highest in patients with a low eGFR.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Kidney Dis

Advancing Transplant Equity by Closing the Gaps in Policy, Practice, and Research.

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Peritoneal Dialysis Prescription and Adequacy in Clinical Practice: Core Curriculum 2023.

A more patient-centered approach emphasizes the importance of individualized treatment, particularly when considering incremental PD and other prescriptions that align with lifestyle preferences. In shifting the focus from small solute clearance targets to patient needs and clinical goals, PD remains an attractive, patient-centered form of kidney replacement therapy.

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Social and Financial Implications of Medicare Part B Immunosuppressive Drug Benefits for Kidney Transplant Recipients: A View from the Trenches.

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J Am Soc Nephrol

Is Home Dialysis the Way Forward for Medicare? Assessing Potential Cost Savings Associated with Peritoneal Dialysis.

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Kidney Int

Blood pressure effects of sodium transport along the distal nephron.

However, what also has become clear is that aldosterone itself only stimulates a portion of the mineralocorticoid receptors along this segment, with the others being activated by glucocorticoid hormones instead. These recent insights provide an increasingly clear picture of how this short nephron segment contributes to blood pressure homeostasis and have important implications for hypertension prevention and treatment.

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Nat Rev Nephrol

Cisplatin nephrotoxicity: new insights and therapeutic implications.

However, the effects of renoprotective strategies on the efficacy of cisplatin chemotherapy needs to be thoroughly evaluated. Further research using tumour-bearing animals, multi-omics and genome-wide association studies will enable a comprehensive understanding of the complex cellular and molecular mechanisms of cisplatin nephrotoxicity and potentially lead to the identification of specific targets to protect the kidney without compromising the chemotherapeutic efficacy of cisplatin.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Clin J Am Soc Nephrol

Accepting Living Kidney Donors with Preexisting Diabetes Mellitus.

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J Am Soc Nephrol

The ABCD of Kidney Allograft Pathology-the Beginning of the Beginning.

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Kidney Int

False positivity for PLA2R1-antibody measured by ELISA in a nephrotic patient with no membranous nephropathy.

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Nephrol Dial Transplant

Towards a tailored prescription of dialysis adequacy: the key role of incremental hemodialysis.

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Letters&Replies

Letters to the editors and authors’ replies

Am J Kidney Dis

Prognostic Value of Diffuse Crescentic Lesions in Fibrillary Glomerulonephritis.

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Short-term Healthy Lifestyle Intervention and Long-term Behavior Change After Kidney Transplantation: Findings From the CAVIAR Study.

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J Am Soc Nephrol

Targeting the Right Metrics for Kidney Transplantation Success.

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